Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.

Julia Barthelmes,Anika Männer de Bazo,Yael Pewzner-Jung,Katja Schmitz,Christoph A Mayer,Christian Foerch,Max Eberle,Nadja Tafferner,Nerea Ferreirós,Marina Henke,Gerd Geisslinger,Anthony H Futerman,Sabine Grösch,Susanne Schiffmann

Brain, Behavior, and Immunity（2015）

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摘要

•CerS2/C24-ceramides are upregulated in white blood cells of EAE mice and MS patients.•CerS2 deficiency reduces pathology of EAE.•CerS2 deficiency reduces migration capacity of neutrophils.•G-CSF induces the expression of CerS2 and C24-ceramides.•G-CSF induced migration of neutrophils is CerS2-dependent regulation via CXCR2 expression.

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关键词

BM,CCL,CCR,Cer,CerS,CNS,dhCer,EAE,ERK,FACS,G-CSF,LacCer,MOG,MS,PMS,PCR,RRMS,WBC,WT

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