A study to investigate changes in the levels of biomarkers of exposure to selected cigarette smoke constituents in Japanese adult male smokers who switched to a non-combustion inhaler type of tobacco product.

•A non-combustion inhaler type of tobacco product (NCIT) was investigated.•Clinical study was conducted with 60 Japanese male smokers and 20 non-smokers.•Change in levels in 14 biomarker of exposure (BOE) were monitored for 4weeks.•Switching from cigarette to NCIT showed significant reduction in all BOEs measured.•BOEs in nonsmokers indicated the extent of the exposure from living environment.