Evaluation of a LC-MS method for everolimus preclinical determination in brain by using [(13)C2D4]RAD001 internal standard.

Stefano Giovagnoli,Tommaso Cassano,Lorenzo Pace,Alessandro Magini,Alice Polchi,Brunella Tancini,Marzia Perluigi,Federico De Marco,Carla Emiliani,Diego Dolcetta

Journal of Chromatography B（2015）

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摘要

•Samples were obtained from vehicle and everolimus-treated C57BL/6 mice.•(13C2D4)RAD001 was evaluated for the first time on brain tissue samples.•Good method performance on a wide range of concentrations.•The use of (13C2D4)RAD001 limits biological matrix effects.•The method could be used for preclinical monitoring of everolimus.

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关键词

Biological samples,LC–MS,Everolimus,Isotopically labeled internal standard,Brain levels

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