Prevalence of high-risk human papilloma virus genotypes and associated risk of cervical precancerous lesions in a large U.S. screening population: data from the ATHENA trial.

•HPV 16 was the most common genotype in all populations and conferred the highest risk for high grade disease.•We found that 50% of the adenocarcinoma in situ and 50% of the invasive cancer cases were attributable to HPV18 infection.•We confirmed the utility of 16/18 genotyping in cervical cancer screening strategies, while pooled detection of non-16/18 genotypes is sufficient.