Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease.

Veronika Boczonadi,Michele Giunta,Maria Lane,Mar Tulinius,Ulrike Schara,Rita Horvath

The International Journal of Biochemistry & Cell Biology（2015）

引用 14|浏览5

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摘要

•We show a developmental isoform switch of COX6A/COX7A in muscle of humans and mice.•Liver isoforms are present at birth; heart/muscle isoforms increase ∼3 months of age.•The physiological isoform switch does not explain reversible mitochondrial disease.•Developmental changes of COX isoforms may modify other mitochondrial diseases.

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关键词

Reversible infantile respiratory chain deficiency,Cytochrome c oxidase,Isoform switch,Mitochondrial tRNAGlu

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