Overcoming multiple drug resistance by spatial-temporal synchronization of epirubicin and pooled siRNAs.

Wei Chen,Xueyao Liu,Yun Xiao,Ruikang Tang

SMALL（2015）

引用 16|浏览7

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摘要

One-pot solution mineralization can encapsulate epirubicin (EPI) and pooled siRNAs (Pgp and Bcl-2 siRNAs) in calcium phosphate (CaP). The resulting EPI-RNA-CaP nanocomplexes can achieve a spatial-temporal synchronous effect to full-scale overcome sophisticated multiple drug resistance (MDR) by simultaneous inhibitions of drug efflux and intracellular anti-apoptotic defense to maximize the therapeutic efficacy.

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关键词

epirubicin,multiple drug resistance,RNA interference,gene therapy,synergistic effect

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