C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy.

Nithin B Boppana,Ursula Stochaj,Mohamed Kodiha,Alicja Bielawska,Jacek Bielawski,Jason S Pierce,Mladen Korbelik,Duska Separovic

Journal of Photochemistry and Photobiology B: Biology（2015）

引用 8|浏览11

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摘要

•PDT+C6-pyridinium ceramide (LCL29) enhance caspase-dependent cell death.•Ceramide synthase inhibitor fumonisin B1 (FB) rescues cells from death post-PDT±LCL29.•PDT+LCL29 enhance FB-sensitive mitochondrial ceramide accumulation.•PDT+LCL29 enhance FB-sensitive cytochrome c redistribution.•PDT+LCL29 enhance FB-sensitive caspase-3 activation.

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