Protective effects of cholecystokinin-8 on methamphetamine-induced behavioral changes and dopaminergic neurodegeneration in mice.

Hongyan Gou,Di Wen,Chunling Ma,Ming Li,Yingmin Li,Wenfang Zhang,Li Liu,Bin Cong

Behavioural Brain Research（2015）

引用 21|浏览37

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摘要

•Repeated administration of METH induced behavioral changes and dopaminergic neurotoxicity in mice.•CCK-8 attenuated METH-induced behavioral sensitization and stereotypic behaviors in mice.•CCK-8 inhibited hyperthermia and reduction of nigrostriatal TH and DAT in METH-treated mice.

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关键词

CCK-8,Methamphetamine,Sensitization,Stereotypic behavior,Neurodegeneration

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