Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.

Antonia Langfelder,Emeka Okonji,Diana Deca,Wei-Chun Wei,Maike D Glitsch

Cell Calcium（2015）

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摘要

•External acidosis affects P2Y receptor dependent Ca2+ signalling in microglia.•External acidosis strongly reduced P2Y receptor dependent Ca2+ influx.•There was little impact of external acidosis on P2Y receptor dependent Ca2+ release.•Extracellular acidosis inhibited P2Y receptor induced but not basal migration.

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关键词

P2Y receptors,Microglia,Acidosis,Store-operated Ca2+ entry,Migration

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