Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis.
Biochemical and Biophysical Research Communications(2015)
摘要
Intra- and inter-tumor heterogeneity may hinder personalized molecular-target treatment that depends on the somatic mutation profiles. We performed mutation profiling of formalin-fixed paraffin embedded tumors of multi-regional colon cancer and characterized the consequences of intra- and inter-tumor heterogeneity and metastasis using targeted re-sequencing.
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关键词
Colorectal cancer,RAS mutation,Heterogeneity
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