Oncostatin M binds to extracellular matrix in a bioactive conformation: implications for inflammation and metastasis.

Randall E Ryan,Bryan Martin,Liliana Mellor,Reed B Jacob,Ken Tawara,Owen M McDougal,Julia Thom Oxford,Cheryl L Jorcyk

Cytokine（2015）

引用 40|浏览8

暂无评分

摘要

•OSM binding to ECM is pH-dependent and involves electrostatic bonds.•Immobilized OSM is bioactive and induces prolonged phosphorylation of STAT3.•The novel ‘OSM circle’ assay validates immobilized OSM bioactivity.•Immobilized OSM is protected from proteolysis.•A model for the role of immobilized OSM in inflammation and metastasis is developed.

查看译文

关键词

OSM,gOSM,IL-6,LIF,PBS,TBS,TTBS,DTT,TX,NC4, Col-I,Col-XI,Lam,Fn,ECM,EMT,SPR,MWs,TGF-β,HGF,SFM,CM,kDa,FBS

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要