The intrarenal generation of angiotensin II is required for experimental hypertension.

Jorge F Giani,Kandarp H Shah,Zakir Khan, Ellen A Bernstein,Xiao Z Shen,Alicia A McDonough,Romer A Gonzalez-Villalobos,Kenneth E Bernstein

Current Opinion in Pharmacology（2015）

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摘要

•All components of the RAS are expressed in the kidney.•Evidence suggests that the renal RAS functions as a separate entity from systemic RAS.•Local generation of angiotensin II by renal ACE is essential for hypertension.•Mice lacking renal ACE are protected against hypertension.

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