A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells.

Claudia Ceci,Maria Luisa Barbaccia,Giuseppa Pistritto

NeuroToxicology（2015）

引用 6|浏览10

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摘要

•We investigated whether NT2 cells neuronal differentiation was affected by nickel.•Nickel (10μM) increased the expression of differentiation markers MAP2 and NCAM.•Nickel activated the AKT/PKB kinase pathway and increased HIF-1a expression/accumulation.•Tyrosine hydroxylase mRNA was unchanged, but the protein was lower in Ni-treated NT2 cells.•The results suggest that nickel may increase vulnerability to neuro-psychopathology.

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关键词

Microtubule-associated-protein2/MAP2,Neural cell adhesion molecule/NCAM,Hypoxia-inducible-factor-1α/HIF-1α,Glycogen synthase kinase/GSK-3β,Tyrosine hydroxylase/TH

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