One step creation of multifunctional 3D architectured hydrogels inducing bone regeneration.

Axel T Neffe,Benjamin F Pierce,Giuseppe Tronci,Nan Ma,Erik Pittermann,Tim Gebauer,Oliver Frank,Michael Schossig,Xun Xu,Bettina M Willie, Michèle Forner,Agnes Ellinghaus,Jasmin Lienau,Georg N Duda,Andreas Lendlein

Advanced materials (Deerfield Beach, Fla.)（2015）

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摘要

Structured hydrogels showing form stability and elastic properties individually tailorable on different length scales are accessible in a one-step process. They support cell adhesion and differentiation and display growing pore size during degradation. In vivo experiments demonstrate their efficacy in biomaterial-induced bone regeneration, not requiring addition of cells or growth factors.

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