Trivalent pneumococcal protein recombinant vaccine protects against lethal Streptococcus pneumoniae pneumonia and correlates with phagocytosis by neutrophils during early pathogenesis.

Qingfu Xu,Naveen Surendran,David Verhoeven,Jessica Klapa,Martina Ochs,Michael E Pichichero

Vaccine（2015）

引用 18|浏览7

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摘要

•PPrV vaccination led to elevated IgG level and protection against Spn challenge.•Vaccinated mice had lower lung Spn burden and inflammation after challenge.•PPrV protection correlates to higher level of phagocytosis of Spn by neutrophils.

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关键词

Streptococcus pneumoniae,Infant murine model,Pneumococcal protein vaccine,Phagocytosis,Neutrophils,Alveolar macrophages

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