The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis.

Marcel Schouten,Cornelis van 't Veer,Nadia Poulussen,Joost C M Meijers,Marcel Levi,Charles T Esmon,Tom van der Poll

Thrombosis Research（2015）

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摘要

•Endogenous PC inhibits pulmonary and systemic coagulation in pneumococcal infection.•The cytoprotective effects of APC inhibit coagulation in pneumococcal infection.•Endogenous APC has small impact on fibrinolysis in pneumococcal infection.•Endogenous APC has small impact on inflammation in pneumococcal infection.

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关键词

coagulation,S. pneumoniae,inflammation,pneumonia,protein C,sepsis

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