Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer.

Yuexia Li,Xiaohui Li,Gang Liu,Rongqing Sun,Lirui Wang,Jing Wang,Hongmin Wang

Biochemical and Biophysical Research Communications（2015）

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摘要

•TIPE2 is down-regulated in NSCLC tissues.•TIPE2 inhibits NSCLC cell proliferation, colony formation and invasion.•TIPE2 reduces the anti-apoptotic Bcl-XL protein and mesenchymal marker N-cadherin expression.

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关键词

TIPE2,Non-small cell lung cancer,Tumor suppressor,Proliferation,Invasive

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