Synthesis and biological activities of vitamin D3 derivatives with cyanoalkyl side chain at C-2 position.

Hiroshi Saitoh,Hidekazu Watanabe,Shinji Kakuda,Midori Takimoto-Kamimura,Kenichiro Takagi,Akiko Takeuchi,Kazuya Takenouchi

The Journal of Steroid Biochemistry and Molecular Biology（2015）

引用 8|浏览6

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摘要

•We synthesized vitamin D3 derivatives with cyanoalkyl side chain at C-2 position.•These novel derivatives showed strong transactivation activities.•Nitrogen atom in the 2α-side chain is able to form a novel interaction.

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关键词

Vitamin D3,2α-Functionalized vitamin D,Vitamin D receptor,Binding affinity,Transactivation,X-ray co-crystallographic analysis

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