Copper-binding tripeptide motif increases potency of the antimicrobial peptide Anoplin via Reactive Oxygen Species generation.

M Daben J Libardo,Sai Nagella,Andrea Lugo,Scott Pierce,Alfredo M Angeles-Boza

Biochemical and Biophysical Research Communications（2015）

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摘要

•An ATCUN motif potentiates the antimicrobial activity of the antimicrobial peptide Anoplin.•The addition of the ATCUN motif results in a decrease of Anoplin’s α helical content.•The presence of the ATCUN motif promoted oxidative damage of the bacterial membrane.

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关键词

Antimicrobial peptide,ATCUN,Reactive Oxygen Species,Bioinorganic chemistry

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