Interception of host angiogenic signalling limits mycobacterial growth

Stefan H. Oehlers,Mark R. Cronan,Ninecia R. Scott, Monica I. Thomas,Kazuhide S. Okuda,Eric M. Walton,Rebecca W. Beerman,Philip S. Crosier,David M. Tobin

NATURE（2014）

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摘要

Using a model of tuberculosis in zebrafish, granuloma formation is shown to coincide with hypoxia and angiogenesis; furthermore, the pharmacological inhibition of the pro-angiogenic VEGF pathway reduces infection burden, suggesting a possible treatment strategy in patients with the disease.

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关键词

Tuberculosis, Monocytes and macrophages, Pathogens

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