Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a.

E Arduin,S Arora,P R Bamert,T Kuiper,S Popp,S Geisse,R Grau,T Calzascia,G Zenke,J Kovarik

Molecular Immunology（2015）

引用 57|浏览6

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摘要

•Introduction of two silencing Fc mutations in a mouse IgG backbone.•LALA and N297 Fc mutation in mouse IgG2a reduce binding to mouse FcγRs.•LALA and N297 Fc mutation in mouse IgG2a reduce binding to human C1q.

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关键词

Mouse IgG2a,Fc silencing mutations,Mouse FcγRs binding,Complement

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