Sleep loss activates cellular inflammation and signal transducer and activator of transcription (STAT) family proteins in humans.

Michael R Irwin,Tuff Witarama,Marissa Caudill,Richard Olmstead,Elizabeth Crabb Breen

Brain, Behavior, and Immunity（2015）

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摘要

•Sleep loss activates spontaneous cellular innate immunity.•Sleep loss activates spontaneous monocytic production of inflammatory cytokines.•Sleep loss activates signal transducer and activator of transcription family proteins.•Sleep loss promotes an inflammatory microenvironment that increases risk for disease.

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关键词

Sleep,Inflammation,Immunology,Sleep deprivation,Interleukin-6,Tumor necrosis factor-α,Signal transducer and activator of transcription,Flow cytometry,Humans,Monocytes

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