A substitution in nsP1 combined with a double substitution in E2 glycoprotein renders Sindbis-like virus XJ-160 fully neurovirulent for adult mice.

Wuyang Zhu,Lingling Deng,Yan Wei,Huanqin Wang,Jinglin Wang,Guodong Liang

Virus Research（2015）

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摘要

•Construction of recombinant infectious clone.•Production of mutant virus.•Detection of viral growth capacity.•Investigation of Sindbis viral neurovirulence.

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关键词

Sindbis-like virus XJ-160,Neurovirulence,Substitution

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