Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes.

Sabrina Mauf,Marissa Penna-Martinez,Thorsten Jentzsch,Hanns Ackermann,Dirk Henrich,Heinfried H Radeke,Patrick Brück,Klaus Badenhoop,Elizabeth Ramos-Lopez

The Journal of Steroid Biochemistry and Molecular Biology（2015）

引用 23|浏览4

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摘要

•Immunomodulatory effects of 25(OH)D3 and vitamin D polymorphisms in type 1 diabetes.•A case-matched study of patients with type 1 diabetes (T1D) and healthy controls.•25(OH)D3 shows immunomodulatory effects on a cellular level toward self-tolerance.

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(α),(β),(25(OH)D3),(1,25(OH)2D3),(vitamin D3, VD3),(CYP),(CD),(DC, CD11c+/CD14−/CD83+/CD123−/low+),(FACS),(HC),(HLA),(IL),(IC, CD11c+/CD14+/CD83+/CD123−/low+),(MC, CD11c−/CD14+/CD83−/+/CD123−),(NOD),(Tregs),(SNP),(T1D),(tDC),(DBP),(VDR)

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