The macrophage-TCRαβ is a cholesterol-responsive combinatorial immune receptor and implicated in atherosclerosis.

Tina Fuchs,Kerstin Puellmann,Alexander Emmert,Julian Fleig,Septimia Oniga,Rebecca Laird,Nana Maria Heida,Katrin Schäfer,Michael Neumaier,Alexander W Beham,Wolfgang E Kaminski

Biochemical and Biophysical Research Communications（2015）

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摘要

•Identification of a large abundance of TCRαβ+ macrophages within atherosclerotic lesions.•Advanced carotid artery lesions express highly restricted TCRαβ repertoires.•TCR deficient rag−/− mice have an altered macrophage-dependent inflammatory response.•In vitro modulation of macrophage-TCRβ repertoires by cholesterol.

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关键词

Macrophage,Atherosclerosis,TCR,V(D)J immune receptor

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