Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis.

Zuquan Weng,Yong Luo,Xi Yang,James J Greenhaw,Haibo Li,Liming Xie,William B Mattes,Qiang Shi

Toxicology（2015）

引用 49|浏览3

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摘要

•Regorafenib uncouples hepatic mitochondrial oxidative phosphorylation.•Regorafenib causes necrosis but not apoptosis in hepatocytes.•Regorafenib activates AMP-activated protein kinase and autophagy.•Regorafenib cytotoxicity is observed at clinically relevant concentrations.

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关键词

Regorafenib,Hepatotoxicity,Mitochondrion,Rat,Hepatocyte,Necrosis

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