Protein misfolding cyclic amplification (PMCA): Current status and future directions.
Virus Research（2015）
摘要
•PMCA is essential for studying biological and molecular aspects of TSE pathogenesis.•Its sensitivity allows preclinical PrPTSE detection in biological fluids and tissues.•It provides an invaluable matrix for testing potential therapeutic molecules.•PMCA also facilitates risk assessment studies to minimize iatrogenic TSE transmission.•It can be applied to investigate protein conformational disorders such as AD and PD.
更多查看译文
关键词
TSEs,PrPTSE,PrPC,PrPres,PrP27–30,rPrP,PMCA,aPMCA,saPMCA,PK,Mo-vCJD,263K-BH,poly(A),poly(rA),poly(G),POPG,CWD,BSE,CNS,EV,EVP,SP-SC,CPD,BH,wt-MoBH,D2O,RT,PBS,FVB,CSF,PE,α-Syn,AD,PD,Aβ,GPI,sCJD,PrPCWD,rPrP-respoly(rA),BC,WBC
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要