In silico prediction of physical protein interactions and characterization of interactome orphans

Max Kotlyar,Chiara Pastrello,Flavia Pivetta, Alessandra Lo Sardo,Christian Cumbaa,Han Li, Taline Naranian,Yun Niu,Zhiyong Ding,Fatemeh Vafaee, Fiona Broackes-Carter,Julia Petschnigg,Gordon B Mills,Andrea Jurisicova,Igor Stagljar,Roberta Maestro,Igor Jurisica

NATURE METHODS（2014）

引用 120|浏览24

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摘要

This paper presents FpClass, a prediction method for physical protein-protein interactions. The method is benchmarked against experimental data and is used to predict, among others, partners of interactome 'orphans'.

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Proteome informatics

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