PHARMACOKINETIC EVALUATION OF TENOFOVIR DISOPROXIL FUMARATE RELEASED FROM AN INTRAVAGINAL RING IN PIG-TAILED MACAQUES AFTER 6 MONTHS OF CONTINUOUS USE

Background and Methods A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety. Results and Conclusions Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.