Antibacterial, anti-fungal and phytotoxic activities of Ferula narthex Boiss.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES(2014)
摘要
Crude methanolic extract of roots, aerial parts and its subsequent fractions of Ferula narthex Boiss were tested for antibacterial, anti-fungal and phytotoxic activities. Crude methanolic extract of roots and its fractions showed significant antibacterial effect against P.aeruginosa (86.95%, 73.91, 69.59, 78.26 & 73.91%) represented by percent inhibition except ethyl acetate (EtoAc) fraction. The EtoAc fraction of roots and aerial parts showed significant activity against E. coli (80%), S. typhi (81.2 & 81.25%) and S. pneumoniae (80%). The n-hexane, chloroform and aqueous fractions of aerial parts showed significant activity against P. aeruginosa (78.26, 69.56 & 73.91%). Following fungal strains (T longifusus, C. albicans, A. flavus, M canis, F solani, C. glabrata) were also used for anti-fungal activity. Among tested samples only crude methanol extract of roots, n-hexane and chloroform fraction showed moderate antifungal activity against M canis (40, 35 & 30%) represented by percent inhibition. The remaining fractions showed no effect on tested fungi. Different oils fractions were also tested against above fungal strains. Fraction I, II & V showed mild to moderate activity against M canis (40, 40 & 25%). Phytotoxic effect of tested samples of roots, aerial part and its fractions showed concentration dependent growth inhibition. Maximum phytotoxic effect was noted for n-hexane and aqueous fraction (50% growth inhibition). The remaining tested samples showed mild effect on growth of Lemna minor plant.
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关键词
Ferula narthex Boiss,antibacterial,anti-fungal,phytotoxic,Lemna minor
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