7,8-Secolignans from the fruits of Schisandra neglecta

Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3–6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 μM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2–5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8–28.7%. These rates are close to that of a positive control.