Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

Frontiers in genetics, Volume 5, 2014, Pages 342-342.

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Keywords:
chemical similaritydata integrationdrug profilingkinome profilessystems-biologyMore(4+)

Abstract:

The Library of Integrated Network-based Cellular Signatures (LINCS) project is a large-scale coordinated effort to build a comprehensive systems biology reference resource. The goals of the program include the generation of a very large multidimensional data matrix and informatics and computational tools to integrate, analyze, and make th...More

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