CD4(+)Foxp3(+) Tregs protect against innate immune cell-mediated fulminant hepatitis in mice.

Xin Hou,Jing Song,Jun Su,Dake Huang,Wenda Gao,Jun Yan,Jijia Shen

Molecular Immunology（2015）

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摘要

•PolyI:C/d-GalN-induced liver injury is mediated by innate immune cells.•Tregs play an important role in inhibiting polyI:C/d-GalN-induced liver injury.•Tregs secrete TGF-β.•Tregs enhance the production of IL-10 by Kupffer cells.

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关键词

d-Galactosamine,ALT,MNC,LAP

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