Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.

B Fu,J Zhang,X Zhang,C Zhang,Y Li,Y Zhang,T He,P Li,X Zhu,Y Zhao,Y Zhang,X Wang

Neuroscience（2014）

引用 62|浏览13

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摘要

•Alpha-lipoic acid provided defense against cerebral ischemia injury in mice.•Alpha-lipoic acid exerted effect of anti-oxidative stress in pMCAO mice.•Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression.

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关键词

ALA,BW,GAPDH,MCA,MCAO,PCR,PGC-1α,pMCAO,ROS,RT-qPCR,SIRT1,SOD,TTC

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