Vaccination with liposomal poly(I:C) induces discordant maturation of migratory dendritic cell subsets and anti-viral gene signatures in afferent lymph cells.

Melanie R Neeland,Martin J Elhay,Els N T Meeusen,Michael J de Veer

Vaccine（2014）

引用 5|浏览3

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摘要

•Liposomal poly(I:C) increases neutrophil recruitment and antigen uptake by DCs.•Liposomal poly(I:C) induces a unique pattern of migratory DC maturation.•Monocytes up-regulate anti-viral genes but do not mature in response to poly(I:C).•Innate gene expression profiles of sorted cell populations after local vaccination.•The in vivo real time immune response to liposome-based adjuvant delivery system.

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关键词

Vaccination,Antigen uptake,Adjuvant,Migratory dendritic cells,Monocytes,Liposomes,Poly(I:C)

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