Hyperbaric oxygen preconditioning protects lung against hyperoxic acute lung injury in rats via heme oxygenase-1 induction.

Ying Feng,Zinan Zhang,Qiang Li,Weihao Li,Jing Xu,Huifang Cao

Biochemical and Biophysical Research Communications（2015）

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摘要

•HBO-PC ameliorated the biochemical and histological lung alterations induced by hyperoxia.•HBO-PC decreased oxidative products but increased antioxidant enzymes.•HBO-PC up-regulated HO-1 mRNA and activity.•HO-1 inhibitor abolished the protective effects of HBO-PC.

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关键词

Hyperoxic acute lung injury,Oxidative stress,Hyperbaric oxygen preconditioning,Heme oxygenase-1

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