Effects of ERα-specific antagonist on mouse preimplantation embryo development and zygotic genome activation.

Yanqin Zhang,Yufei Jiang,Xiuli Lian,Songhua Xu,Jianen Wei,Chenfeng Chu,Shie Wang

The Journal of Steroid Biochemistry and Molecular Biology（2015）

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摘要

•ERα-specific antagonist MPP blocked the development of mouse 1-cell embryos in vitro.•MPP down-regulated nuclear ERα expression of mouse 2-cell embryos.•MPP decreased the mRNA level of MuERV-L, one of zygotic genome activation genes.

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关键词

ERα,MZT,ZGA,MPP,PHTPP,MuERV-L,Zscan4d,Hsp70.1,eIF1A

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