Dipeptide prodrug approach to evade efflux pumps and CYP3A4 metabolism of lopinavir.

Mitesh Patel,Ye Sheng,Nanda K Mandava,Dhananjay Pal,Ashim K Mitra

International Journal of Pharmaceutics（2014）

引用 6|浏览4

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摘要

•To provide dipeptide prodrug approach to circumvent P-gp and MRP2-mediated efflux of anti-HIV drug, lopinavir.•To provide interaction of dipeptide prodrug with peptide transporters.•To provide a strategy to overcome CYP3A4-mediated metabolism of lopinavir.•To provide a viable option for improving oral absorption of lopinavir.

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关键词

Lopinavir,LPV,Dipeptide prodrug,Uptake,Transport,Permeability,P-gp,MRP2 and metabolism

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