The RNA exosome promotes transcription termination of backtracked RNA polymerase II

Jean-François Lemay,Marc Larochelle,Samuel Marguerat,Sophie Atkinson,Jürg Bähler,François Bachand

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2014）

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摘要

New in vivo analyses in Schizosaccharomyces pombe suggest that the RNA exosome promotes transcription termination by targeting the 3' end of nascent transcripts associated with 'backtracked' RNA polymerase II, revealing a new link between mRNA surveillance and termination.

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nature structural and molecular biology, science

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