Paradoxical response to the sedative effects of diazepam and alcohol in C57BL/6J mice lacking the neuropeptide S receptor.

Pasha Ghazal,Mauro Corsi,Adelheid Roth,Federico Faggioni,Corrado Corti,Emilio Merlo Pick,Sandra Pucciarelli,Roberto Ciccocioppo,Massimo Ubaldi

Peptides（2014）

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摘要

•The NPS system posses anxiolytic-like effects and promotes arousal.•The deletion of NPSR leads to minor changes in the arousal behavior of mice.•The NPSR deletion did not lead to compensatory changes of CRF and Orexin systems.

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关键词

NPS,Sedation,NPSR KO mice,Alcohol,Hcrt-1/Ox-A,CRF

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