Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development.

•NOS3 (E298D) and NOS2A (exon 22) SNPs associated with sepsis development.•NOS3 (E298D) SNP T allele septic carriers showed increased plasma NOx levels compared with carriers of other genotypes of this SNP.•NOS SNPs association with sepsis might be mediated by increased plasma NOx levels leading to hemodynamic failure and fatal outcome.