Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC.

Odeta Arandarcikaite,Ramunas Jokubka,Vilmante Borutaite

Neuroscience Letters（2015）

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摘要

•Brain ischemia causes early inhibition of mitochondrial respiration at complex I.•There is no release of cytochrome c from mitochondria during brain ischemia.•Brain ischemia causes opening of mitochondrial permeability transition pore (MPTP).•Injection of NOC-18 in rats protects against ischemia-induced MPTP and necrosis.•NOC-18-induced protective mechanism is mediated by PKG and PKC.

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关键词

CRC,LDH,MPTP,NOC-18,NOS,PKG,PKCɛ

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