Structural basis for the assembly of the Sxl–Unr translation regulatory complex

Janosch Hennig,Cristina Militti,Grzegorz M. Popowicz,Iren Wang,Miriam Sonntag,Arie Geerlof,Frank Gabel,Fátima Gebauer,Michael Sattler

NATURE（2014）

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摘要

The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex, highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein–RNA architecture.

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关键词

X-ray crystallography, RNA-binding proteins, Translation, Developmental biology

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