Treatment of Aspergillus terreus infections: a clinical problem not yet resolved.

•The therapy success in IA by Aspergillus terreus is determined by many factors.•Treatment with itraconazole has variable success.•Voriconazole PK interpatient variability is determined by CYP2C19 polymorphisms.•The use of posaconazole for the treatment of IA by A. terreus is promising.•Low antifungal MICs are not definitive markers of A. terreus susceptibility.