The human SRCAP chromatin remodeling complex promotes DNA-end resection.

Shunli Dong,Jinhua Han,Hongxia Chen,Ting Liu,Michael S Y Huen,Yeran Yang,Caixia Guo,Jun Huang

Current Biology（2014）

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摘要

•SRCAP is a DNA damage response protein•SRCAP promotes DNA-end resection and homologous recombination repair•SRCAP forms a complex with CtIP and is required for CtIP accumulation at DSBs•SRCAP facilitates DNA-end resection by promoting chromatin relaxation

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