Mannose-6-phosphate facilitates early peripheral nerve regeneration in thy-1-YFP-H mice.

•We have visualized and quantified nerve regeneration at an axonal level.•Axons cross the repair site more directly following mannose-6-phosphate treatment.•Mannose-6-phosphate alters axon sprouting just distal to axon entry into the graft.•Mannose-6-phosphate may enable more favorable collagen fibril alignment.•Our data add further evidence that mannose-6-phosphate improves nerve regeneration.