Endothelium-dependent and -independent vasorelaxant actions and mechanisms induced by total flavonoids of Elsholtzia splendens in rat aortas.

Hui-Ping Wang,Jian-Feng Lu,Guo-Lin Zhang,Xu-Yun Li,Hong-Yun Peng,Yuan Lu,Liang Zhao,Zhi-Guo Ye,Iain C Bruce,Qiang Xia,Ling-Bo Qian

Environmental Toxicology and Pharmacology（2014）

引用 17|浏览26

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摘要

•Total flavonoids of E. splendens (TFES) relaxed aorta regardless of endothelium.•NOS/NO/cGMP pathway likely mediates endothelium-dependent relaxation by TFES.•KATP and Ca2+ channels might mediate endothelium-independent relaxation by TFES.

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关键词

Total flavonoids of Elsholtzia splendens,Aorta,Vasorelaxation,Endothelium,Calcium channels,Potassium channels

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