Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

Gerald Wirnsberger,Florian Zwolanek,Johannes Stadlmann,Luigi Tortola, Shang Wan Liu,Thomas Perlot,Päivi Järvinen,Gerhard Dürnberger,Ivona Kozieradzki,Renu Sarao,Alba De Martino,Kaan Boztug,Karl Mechtler,Karl Kuchler,Christoph Klein,Ulrich Elling,Josef M Penninger

NATURE GENETICS（2014）

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摘要

Josef Penninger and colleagues generate mice with conditional knockout of Jagn1 in hematopoietic cells. They show that the mice have a defective neutrophil-mediated immune response to Candida albicans , and GM-CSF treatment restored the defective fungicidal activity.

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关键词

Immunogenetics,Immunological deficiency syndromes,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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