Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2

A new ( 2 ) and four known ( 1 , 8–10 ) sesquiterpenoids, two new ( 3 and 4 ) and eight known ( 5–7 , 11–15 ) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1 – 15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5 , 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3 , 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4 , 5 and 11 showed activities against intestinal virus EV71.