The glucagon-like peptide 1 receptor agonist enhances intrinsic peroxisome proliferator-activated receptor γ activity in endothelial cells.

Hirohisa Onuma,Kouichi Inukai,Atsuko Kitahara,Rie Moriya,Susumu Nishida,Toshiaki Tanaka,Hidenori Katsuta,Kazuto Takahashi,Yoshikazu Sumitani,Toshio Hosaka,Hitoshi Ishida

Biochemical and Biophysical Research Communications（2014）

引用 12|浏览9

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摘要

•PPARγ activation was involved in the GLP-1-mediated anti-inflammatory action.•Exendin-4 enhanced endogenous PPARγ transcriptional activity in HUVECs.•H89, a PKA inhibitor, abolished GLP-1-induced PPARγ enhancement.•The anti-inflammatory effects of GLP-1 may be explained by PPARγ activation.

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关键词

GLP-1,HUVECs,PKA,IRS-1,JNK,NF-κB,TNFα,ICAM-1,VCAM-1,NADPH,NOX-1,GAPDH,PPRE,HOMA-R,PAI-1

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